Select your country

North & South America

North & South America

Argentina

Local distributor

Argentina

JUSTESA IMAGEN ARGENTINA, S.A.

Viamonte 1328, 9º piso
1053 Buenos Aires
(Argentina)

ph. +5411 4373-0629
Canada
EN | FR
Colombia

Local distributor

Colombia

AJOVECO S.A.S.

Cl. 93b #31,
Bogotá
(Colombia)

ph. +57-1-2189-200
Perù

Local distributor

Perù

REIMED, SCRL

Pasaje Villaran 192-194 U-12
Urb. Los Sauces Surquillo
Lima 15076
(Peru)

ph. 511-448-1087
Fax 511-448-3447
Uruguay

Local distributor

Uruguay

Lifenir S.A.

Justicia 2069
C 11800 Montevideo
(Uruguay)

ph. +5982-400-3020
Fax +5982-4007320
Venezuela

Local distributor

Venezuela

SUFOMECA

Torre Polar Oeste
Plaza Venezuela
Floor 7, Room 7C
Caracas
PO Box 1050
(Venezuela)

ph. +582-12-793-3222
Fax +582-12-781-1923

Europe

Europa

Bosnia-Herzegowina

Local distributor

Bosnia-Herzegowina

MARK Srl

Via S. Michele 334
34170 Gorizia - Italy

ph. +39 0481 21711
Fax +39 0481 20719
Bulgaria

Local distributor

Bulgaria

EWOPHARMA AG

73 Persenk Street
App. 27 - Floor 8
1164 Sofia
(Bulgaria)

ph. +359 29624478
Fax +359 28683968
Croatia

Local distributor

Croatia

MARK Srl

Via S. Michele 334
34170 Gorizia - Italy

ph. +39 0481 21711
Fax +39 0481 20719
Greece

Local distributor

Greece

LERIVA IMAGING S.A.

33 Pigis Avenue &
6 Anapiron Polemou Street
151 27 Melissia
Athens (Greece)

ph. +30 210-6199886
Fax +30 210 61 78 733
Hungary

Local distributor

Ungheria

EWOPHARMA REPRESENTATION OFFICE

Budakeszi ut 73/F
H-1021 Budapest
(Hungary)

ph. +36 12004650
Fax +36 13980316
Malta

Local distributor

Malta

Suratek Ltd

Concordia Place
Triq Il-Halel
Bugibba SPB2529
Malta

ph. +356 2713 1624
Romania

Local distributor

Romania

EWOPHARMA A.G. ROMANIA

B-dul Primaverii 19 -21
Sc. B - Et.1 - Sect. 1
011972 - Bucharest
(Romania)

ph. +40 212601344
Fax +40 212029327
Serbia

Local distributor

Serbia

MARK Srl

Via S. Michele 334
34170 Gorizia - Italy

ph. +39 0481 21711
Fax +39 0481 20719
Slovenia

Local distributor

Slovenia

MARK Srl

Via S. Michele 334
34170 Gorizia - Italy

ph. +39 0481 21711
Fax +39 0481 20719

Eastern Europe, Middle East & Africa

Eastern Europe, Middle East & Africa

Estonia

Local distributor

Estonia

A.Medical

Varkalu Str. 13A, Riga,
LV-1067, Latvia

ph. + 371 67113760
Fax +372 665 18 07
Ethiopia

Local distributor

Ethiopia

Caroga Pharma PVT. Ltd

P.O.Box 12627
Addis Abeba
(Ethiopia)

ph. +251 11 4654944 / 11 4161090
Fax +251 11 4654595
Ghana

Local distributor

Ghana

Cyndex Pharmacy

P.O.Box DS 1165 Dansoman
Accra
(Ghana)

ph. +233 21553370
Fax +233-244366622 / 21850072
Israel

Local distributor

Israel

DEXCEL

Or-Akiva 30600
30600000 Israel
(Israel)

ph. +972-4-6364015
Fax +972-4-6364004
Jordan

Local distributor

Jordan

THE ARAB DRUG STORE

Khaleel Al Salem street
Amman
(Jordan)

ph. +962 6 5502995
Fax +962 6 5502984
Kenya

Local distributor

Kenya

Nairobi X-Rays Supplies Ltd.

P.O. Box 41669
Nairobi
(Kenya)

ph. +254 20446265-6-7-8
Fax +254 20 4448515/17
Lebanon

Local distributor

Lebanon

Unione Pharmaceutic. d'Orient

Rue du Musée Imm. Stephan QtrBadaro
Beyrouth
(Lebanon)

ph. +961 1 396085-6
Fax +961 1 396047
Lettonia

Local distributor

Lettonia

A.Medical

Varkalu Str. 13A, Riga
LV-1067, Latvia

ph. +371 67113760
Lithuania

Local distributor

Lithuania

A.Medical

Varkalu Str. 13A, Riga
LV-1067, Latvia

ph. +371 67113760
Mauritius

Local distributor

Mauritius

The Mauritius Pharmacy

4, Louis Pasteur Str Forest Side
(Mauritius)

ph. +230 6762435
Fax +230 675 1387
Russia

Local distributor

Russia

Joint Stock Company R-Pharm

111, bld. 1, Leninsky Avenue,
119421, Moscow, Russia
Ph. +7 (495) 956-79-37
Fax +7 (495) 956-79-38

Saudi Arabia

Local distributor

Saudi Arabia

SARABEEL COMMERCIAL EST.

Medical Division
P.O. BOX 14795
21434 Jeddah
(Saudi Arabia)

ph. +966 12657 2246
South Africa

Local distributor

South Africa

AXIM - Head Office Midrand

63 Old Pretoria Road
Halfway House Ext 2
Midrand
1685
South Africa

ph. +27 113140140
Fax +27 113140141
Uganda

Local distributor

Uganda

Kampala X-Rays Suppliers

Plot 181 Bombo Rd (KuBbiri)
P.O. Box 9519
Kampala
(Uganda)

ph. +256 41 534313
Fax +256 41 349919
Ukraine

Local distributor

Ukraine

United Arab Emirates

Local distributor

United Arab Emirates

MANARA HEALTHCARE

Concord Tower, 6th Floor
Dubai Media City
PO Box 213593, Dubai
United Arab Emirates

 

ph. +971 4 454 9712
Fax 971 4 454 2310

Asia Pacific

Asia Pacific

Australia

Local distributor

Australia

REGIONAL HEALTH CARE GROUP

3-11 Primrose Avenue Rosebery
NSW 2018 - Sydney
(Australia)

ph. +61 296624144
Fax +61 296626040
Taiwan - China

Local distributor

Taiwan - China

SUPER FORTUNE ENTERPRISE CO LTD

5 F-1 - 42 Sec.1 Ming
Sheng E. Road Jehovah Building
101 Taipei
(Taiwan)

ph. +886 225673456
Fax +886 225319231
India

Local distributor

India

Imaging Products (India) Ltd

Mumbai
(India)

ph. +91 9819725471
Fax +91 2228320208
Indonesia

Local distributor

Indonesia

PT DIPA PHARMALAB INTERSAINS

Jl. Panjang No. 10
Kebon Jeruk
Jakarta 11530
(Indonesia)

ph.  +62 215348644
Fax +62 2153676066
New Zealand

Local distributor

New Zealand

REGIONAL HEALTH LIMITED

19C Orbit Drive
Mairangi Bay
(New Zealand)

ph. +64 94140040
Fax +64 94140041
Pakistan

Local distributor

Pakistan

S. EJAZUDDIN & CO LTD

PO Box 5629 - Zia Plaza
Altaf Hussain Road
74000 Karachi
(Pakistan)

ph. +92 21212032
Fax +92 212629716
Philippines

Local distributor

Philippines

NEW MARKETLINK INTERNATIONAL CORP

Tao Corporate Centre 2291
Don Chino Roches Ave
Ext Makati City Metro
Manila (Philippines)

ph. (632) 836-5838
Singapore

Local distributor

Singapore

LF ASIA PHARMACEUTICAL DIVISION

Healthcare Distribution Centre
24 Penjuru Road (off Penjuru Close)
#03-04 CWT Commodity Hub
(Singapore 609128)

ph. +65 65097629
Thailand

Local distributor

Thailand

Interpharmacare Co., Ltd.

90 Moo 13 Soi Mahacha
Bangpleeyai
Bangplee
Samutprakarn 10540
(Thailand)

ph. + 66 2 675 9140-2
Fax + 66 2 325 0265
Vietnam

Local distributor

Vietnam

HOANG GIA INVESCO, JSC

No 74-76 Hoa Bang Str
Cau Giay
Dist Ha Noi Hanoi
(Viet Nam)

ph. +43 7846952
 

Select your country

Asia

Australia

Local distributor

Australia

REGIONAL HEALTH CARE GROUP

3-11 Primrose Avenue Rosebery
NSW 2018 - Sydney
(Australia)

ph. +61 296624144
Fax +61 296626040
India

Local distributor

India

Imaging Products (India) Ltd

Mumbai
(India)

ph. +91 9819725471
Fax +91 2228320208
Indonesia

Local distributor

Indonesia

PT DIPA PHARMALAB INTERSAINS

Jl. Panjang No. 10
Kebon Jeruk
Jakarta 11530
(Indonesia)

ph.  +62 215348644
Fax +62 2153676066
New Zealand

Local distributor

New Zealand

REGIONAL HEALTH LIMITED

19C Orbit Drive
Mairangi Bay
(New Zealand)

ph. +64 94140040
Fax +64 94140041
Pakistan

Local distributor

Pakistan

S. EJAZUDDIN & CO LTD

PO Box 5629 - Zia Plaza
Altaf Hussain Road
74000 Karachi
(Pakistan)

ph. +92 21212032
Fax +92 212629716
Philippines

Local distributor

Philippines

NEW MARKETLINK INTERNATIONAL CORP

Tao Corporate Centre 2291
Don Chino Roches Ave
Ext Makati City Metro
Manila (Philippines)

ph. (632) 836-5838
Singapore

Local distributor

Singapore

LF ASIA PHARMACEUTICAL DIVISION

Healthcare Distribution Centre
24 Penjuru Road (off Penjuru Close)
#03-04 CWT Commodity Hub
(Singapore 609128)

ph. +65 65097629
Thailand

Local distributor

Thailand

Interpharmacare Co., Ltd.

90 Moo 13 Soi Mahacha
Bangpleeyai
Bangplee
Samutprakarn 10540
(Thailand)

ph. + 66 2 675 9140-2
Fax + 66 2 325 0265
Vietnam

Local distributor

Vietnam

HOANG GIA INVESCO, JSC

No 74-76 Hoa Bang Str
Cau Giay
Dist Ha Noi Hanoi
(Viet Nam)

ph. +43 7846952

North & South America

Argentina

Local distributor

Argentina

JUSTESA IMAGEN ARGENTINA, S.A.

Viamonte 1328, 9º piso
1053 Buenos Aires
(Argentina)

ph. +5411 4373-0629
Colombia

Local distributor

Colombia

AJOVECO S.A.S.

Cl. 93b #31,
Bogotá
(Colombia)

ph. +57-1-2189-200
Perù

Local distributor

Perù

REIMED, SCRL

Pasaje Villaran 192-194 U-12
Urb. Los Sauces Surquillo
Lima 15076
(Peru)

ph. 511-448-1087
Fax 511-448-3447
Uruguay

Local distributor

Uruguay

Lifenir S.A.

Justicia 2069
C 11800 Montevideo
(Uruguay)

ph. +5982-400-3020
Fax +5982-4007320
Venezuela

Local distributor

Venezuela

SUFOMECA

Torre Polar Oeste
Plaza Venezuela
Floor 7, Room 7C
Caracas
PO Box 1050
(Venezuela)

ph. +582-12-793-3222
Fax +582-12-781-1923

Europe

Bosnia-Herzegowina

Local distributor

Bosnia-Herzegowina

MARK Srl

Via S. Michele 334
34170 Gorizia - Italy

ph. +39 0481 21711
Fax +39 0481 20719
Bulgaria

Local distributor

Bulgaria

EWOPHARMA AG

73 Persenk Street
App. 27 - Floor 8
1164 Sofia
(Bulgaria)

ph. +359 29624478
Fax +359 28683968
Croatia

Local distributor

Croatia

MARK Srl

Via S. Michele 334
34170 Gorizia - Italy

ph. +39 0481 21711
Fax +39 0481 20719
Greece

Local distributor

Greece

LERIVA IMAGING S.A.

33 Pigis Avenue &
6 Anapiron Polemou Street
151 27 Melissia
Athens (Greece)

ph. +30 210-6199886
Fax +30 210 61 78 733
Romania

Local distributor

Romania

EWOPHARMA A.G. ROMANIA

B-dul Primaverii 19 -21
Sc. B - Et.1 - Sect. 1
011972 - Bucharest
(Romania)

ph. +40 212601344
Fax +40 212029327
Serbia

Local distributor

Serbia

MARK Srl

Via S. Michele 334
34170 Gorizia - Italy

ph. +39 0481 21711
Fax +39 0481 20719
Slovenia

Local distributor

Slovenia

MARK Srl

Via S. Michele 334
34170 Gorizia - Italy

ph. +39 0481 21711
Fax +39 0481 20719
Ungheria

Local distributor

Ungheria

EWOPHARMA REPRESENTATION OFFICE

Budakeszi ut 73/F
H-1021 Budapest
(Hungary)

ph. +36 12004650
Fax +36 13980316

Eastern Europe, Middle East & Africa

Ethiopia

Local distributor

Ethiopia

Caroga Pharma PVT. Ltd

P.O.Box 12627
Addis Abeba
(Ethiopia)

ph. +251 11 4654944 / 11 4161090
Fax +251 11 4654595
Ghana

Local distributor

Ghana

Cyndex Pharmacy

P.O.Box DS 1165 Dansoman
Accra
(Ghana)

ph. +233 21553370
Fax +233-244366622 / 21850072
Israel

Local distributor

Israel

DEXCEL

Or-Akiva 30600
30600000 Israel
(Israel)

ph. +972-4-6364015
Fax +972-4-6364004
Jordan

Local distributor

Jordan

THE ARAB DRUG STORE

Khaleel Al Salem street
Amman
(Jordan)

ph. +962 6 5502995
Fax +962 6 5502984
Kenya

Local distributor

Kenya

Nairobi X-Rays Supplies Ltd.

P.O. Box 41669
Nairobi
(Kenya)

ph. +254 20446265-6-7-8
Fax +254 20 4448515/17
Lebanon

Local distributor

Lebanon

Unione Pharmaceutic. d'Orient

Rue du Musée Imm. Stephan QtrBadaro
Beyrouth
(Lebanon)

ph. +961 1 396085-6
Fax +961 1 396047
Mauritius

Local distributor

Mauritius

The Mauritius Pharmacy

4, Louis Pasteur Str Forest Side
(Mauritius)

ph. +230 6762435
Fax +230 675 1387
Saudi Arabia

Local distributor

Saudi Arabia

SARABEEL COMMERCIAL EST.

Medical Division
P.O. BOX 14795
21434 Jeddah
(Saudi Arabia)

ph. +966 12657 2246
South Africa

Local distributor

South Africa

AXIM - Head Office Midrand

63 Old Pretoria Road
Halfway House Ext 2
Midrand
1685
South Africa

ph. +27 113140140
Fax +27 113140141
Uganda

Local distributor

Uganda

Kampala X-Rays Suppliers

Plot 181 Bombo Rd (KuBbiri)
P.O. Box 9519
Kampala
(Uganda)

ph. +256 41 534313
Fax +256 41 349919
Ukraine

Local distributor

Ukraine

Results from the Largest Ever CNS MR Crossover Investigation Published by RSNA Journal Radiology

08/01/2006

Results from a large multicenter, randomized, double blind crossover, intraindividual comparison of two contrast agents for magnetic resonance imaging (MRI) have been published online by Radiology.  In the study titled "Contrast Enhancement of Central Nervous System Lesions: Multicenter Intraindividual Crossover Comparative Study of Two MR Contrast Agents" the authors conclude: the findings in our study indicate that MultiHance®(gadobenate dimeglumine) injection, 529 mg/mL provides significantly improved conspicuity of CNS lesions and greater lesion-to-brain enhancement than does Magnevist® (gadopentetate dimeglumine) injection, at the same dose.


One of the study’s principal investigators, Ken Maravilla, MD, of the University of Washington in Seattle, Washington, said the study produced "significant findings relative to the performance of one of the most widely used gadolinium agents administered in MRI procedures to improve the conspicuity and detectability of central nervous system (CNS) lesions."
Also known as the "MH-109" clinical trial, the study compared equivalent doses (0.1 mmol/kg, 0.2 mL/kg) of MultiHance and Magnevist in 157 patients referred for contrast-enhanced MR examinations of the brain or spine.  Each patient received both agents and acted as his/her own control.


"The key importance of this study is that it was the largest clinical investigation of this kind ever to focus on contrast agents used for MRI," said Maravilla.  "And, it showed some clear advantages relative to performance associated with using the higher relaxivity agent versus another well known widely used gadolinium agent.  I think readers of Radiology will find the details in the publication to be compelling."


Statistically significant (p<0.0001; all readers, all comparisons) results for MultiHance were demonstrated for each individual diagnostic information endpoint used in the study, as well as quantitative parameters linked to the contrast enhancement obtained with the two agents (percent of enhancement of signal intensity in the CNS lesions, contrast-to-noise ratio, CNR).  The authors noted that the greater contrast enhancement achieved with MultiHance corresponds with that which would be expected by doubling the dose of Magnevist, as might be expected on the basis of the roughly twofold greater T1 relaxivity of MultiHance in blood.


The design and conduct of study MH-109 were very rigorous and well suited to compare the performance of the two agents.  The two contrast injections were performed in a blinded and fully randomized manner with an interval of 2–7 days between administrations, to avoid any carryover effects.  Half of the patients received MultiHance for their first exam and the remaining half received Magnevist first.  Imaging parameters and post-dose acquisition times were kept identical for the two exams in each patient.  Images were evaluated by three independent and experienced neuroradiologists, who were unaffiliated with the enrollment centers and fully blinded to any clinical information about the patients and the agents used in the two exams.  Image assessments were made in terms of diagnostic information (lesion border delineation, definition of disease extent, visualization of lesion internal morphology, lesion contrast enhancement) and quantitative parameters (percent of enhancement and CNR). 

Bracco received FDA approval to market MultiHance in the USA in November 2004.  MultiHance is indicated for intravenous use in MRI of the central nervous system in adults to visualize lesions with abnormal blood brain barrier or abnormal vascularity of the brain, spine and associated tissues. 
MultiHance has features that distinguish it from other contrast agents.  As reported in the FDA-approved package insert, MultiHance, unlike other available gadolinium contrast agents, demonstrates weak and transient interactions with serum proteins, which result in a proton magnetic relaxivity that is approximately twice that of Magnevist.  The higher relaxivity of MultiHance may result in greater signal intensity enhancement and better contrast enhancement at equivalent dose.
"Bracco Diagnostics believes that MultiHance offers significant clinical and operational advantages in the MRI arena, and we are pleased that this large-scale, clinical investigation took place," noted Carlo Medici, president and chief executive officer of Bracco Diagnostics Inc.


About MultiHance
As with all paramagnetic agents, caution should be exercised in patients with deoxygenated sickle erythrocytes.
The possibility of a reaction, including serious, life-threatening, or fatal, anaphylactic or cardiovascular reactions, or other idiosyncratic reactions, should always be considered, especially in those patients with a history of known clinical hypersensitivity or a history of asthma or allergic respiratory disorders.


About Bracco

The Bracco Group is a world leading provider of global diagnostic imaging solutions, with net sales of about 800 million Euros per year.  Bracco has operations in 115 countries and about 2,200 employees, around 400 of whom work in R & D.  Bracco invests approximately 15% of its annual turnover in R & D and has a portfolio of 1,500 patents worldwide.
The Bracco Group is a leader in the diagnostic imaging market with an integrated product offering from a diverse roster of subsidiary companies.  While Bracco is recognized internationally as a definitive market leader in its core business of contrast media, Bracco also markets key diagnostic imaging resources through the following companies:  ACIST Medical Systems, a manufacturer of advanced contrast media injection systems and Singapore-based Volume Interactions, which also produces advanced 3-D medical software.
Bracco also operates a high-level international research network, with three centers (Milan, Geneva, and Princeton).  These centers develop products of the latest-generation diagnostic techniques, from X-ray and computed tomography (CT) to magnetic resonance imaging (MRI), echocontrast and nuclear medicine.
For further information, please visit www.multihanceUSA.com.
Magnevist is a registered copyright of Berlex Imaging.

 


IMPORTANT NOTICE:  This press pack also includes some products' commercial brands, which are not to be used unless by media addressed to the medical community.

 

Kirk Deeter
Bracco Diagnostics Inc. Press Office
Telephone:  303.878.8308
Email:  kirkdeeter@wildblue.net